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Table 5 Summary of estrogenic regulation of neuroinflammatory genes.

From: Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats

Symbol Gene name RQ(E2) RQ(LE2) RQ(DPN)
Analogous changes
C3 complement C3 0.703 0.743 0.801
Ccl2 chemokine (C-C) ligand 2 0.527 0.824 0.703
Fcgr2b Fc fragment of IgG, receptor 0.615 0.649 0.651
IgG-2a Ig chain 8.228 9.257 4.048
Il6 interleukin-6 2.823 2.232 2.635
Itgam CD11b 0.571 0.655 0.798
Np4 defensin NP-4 precursor 2.562 2.268 2.578
RatNP-3b defensin ratNP-3 precursor 13.266 10.568 4.574
RT1-Aw2 RT1 class Ib 0.606 0.658 0.463
E2-specific changes
C4b C4 0.670 0.881 0.785
Cx3cr1 fractalkine receptor 0.820 0.914 1.041
Esr1 estrogen receptor-α 1.392 1.169 0.908
Mpeg1 macrophage expressed gene 1 0.611 0.978 0.869
Tgfb1 transforming growth factor beta 1 0.779 0.921 0.938
Tlr4 Toll-like receptor 4 0.810 0.993 1.069
Tlr9 Toll-like receptor 9 0.737 0.896 0.845
  1. The effects of isotype selective ER agonists on the transcription of E2-regulated genes revealed two groups: analogous and specific changes. The large number of analogous changes (genes which are regulated similarly by the three ER agonists) revealed that both ERα and ERβ were involved in the transcriptional regulation of neuroinflammatory genes.