Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats

Table 5 Summary of estrogenic regulation of neuroinflammatory genes.

Symbol	Gene name	RQ(E2)	RQ(LE2)	RQ(DPN)
Analogous changes
C3	complement C3	0.703	0.743	0.801
Ccl2	chemokine (C-C) ligand 2	0.527	0.824	0.703
Fcgr2b	Fc fragment of IgG, receptor	0.615	0.649	0.651
IgG-2a	Ig chain	8.228	9.257	4.048
Il6	interleukin-6	2.823	2.232	2.635
Itgam	CD11b	0.571	0.655	0.798
Np4	defensin NP-4 precursor	2.562	2.268	2.578
RatNP-3b	defensin ratNP-3 precursor	13.266	10.568	4.574
RT1-Aw2	RT1 class Ib	0.606	0.658	0.463
E2-specific changes
C4b	C4	0.670	0.881	0.785
Cx3cr1	fractalkine receptor	0.820	0.914	1.041
Esr1	estrogen receptor-α	1.392	1.169	0.908
Mpeg1	macrophage expressed gene 1	0.611	0.978	0.869
Tgfb1	transforming growth factor beta 1	0.779	0.921	0.938
Tlr4	Toll-like receptor 4	0.810	0.993	1.069
Tlr9	Toll-like receptor 9	0.737	0.896	0.845

The effects of isotype selective ER agonists on the transcription of E2-regulated genes revealed two groups: analogous and specific changes. The large number of analogous changes (genes which are regulated similarly by the three ER agonists) revealed that both ERα and ERβ were involved in the transcriptional regulation of neuroinflammatory genes.

ISSN: 1742-2094