Figure 10

Seizure-induced alteration of significant genes from cellular movement, cell death, and cell morphology gene network. The top eight genes within the network shown in Figure 9 significantly altered by sarin-induced seizure. Interleukin 1 receptor type II (IL1R2), glycoprotein (transmembrane) NMB (GPNMB), tubulin β6 (TUBB6), heme oxygenase (decycling) 1 (HMOX1), and lamin A (LMNA) expression increased over the 24-h time course. GTP binding protein (gene overexpressed in skeletal muscle) (GEM) increased from 0.25 to 3 h after seizure onset, decreased at 6 h, and increased again at 24 h. The expression level of emerin (EMD) peaked at 3 and 6 h after seizure onset and dropped at 24 h. CASP8 and FADD-like apoptosis regulator (CFLAR) had a modest decrease in expression at 1 h after seizure onset and then increased in expression over the remainder of the time course.