Inflammatory-related pathways identified among the most significantly altered pathways in sarin-exposed seizing animals. An ANOVA was performed to identify genes most significantly changed at each time point based on exposure (sarin vs. vehicle). The p-value and geometric fold change for each probeset were imported into IPA to identify the biological functions and canonical pathways most affected by sarin-induced seizure at each time point. Genes from the dataset that met the p-value cutoff and were associated with a canonical pathway in the IPA Knowledge Base were considered for the analysis. The significance of the association between the dataset and the canonical pathway was measured using a p-value that was calculated using Fisher's exact test to determine the probability that the association between the genes in the dataset and the canonical pathway was explained by chance alone. The calculated p-values for each time point are displayed as colored bars, with a threshold of 0.05 (or 1.3 when expressed as -log(p-value)) marked by an asterisk.