Figure 6

Seizure-induced alteration of significant genes from cell-to-cell signaling and interaction, inflammatory response, and cellular movement gene network. The top nine genes within the network shown in Figure 5 significantly altered by sarin-induced seizure. Expression of each gene was up-regulated after seizure onset and continued to rise over the 24-h time period. An exception to this trend was seen with chemokine (C-C motif) ligand 3 (CCL3) and tumor necrosis factor alpha induced protein 6 (TNFAIP6), where expression modestly dropped at 6 h. CCL3 expression continued to drop at 24 h, while TNFAIP6 expression went back up at 24 h after seizure onset.