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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin

Figure 2

Canonical pathways significantly altered in all five brain regions of sarin-exposed seizing animals. A one-way ANOVA was performed to identify genes significantly changed in each brain region at each time point based on exposure (sarin vs. saline). The p-value and geometric fold change for each probeset ID were imported into IPA to identify the biological functions and canonical pathways most significantly affected by sarin-induced seizure at each time point. The top 800 genes that met the p-value cutoff (≤ 0.05) and were associated with a canonical pathway in the IPA Knowledge Base were considered for the analysis. The significance of the association between the dataset and the canonical pathway was calculated using Fisher's exact test. The -log of the p-value is graphed for each time point, with a threshold of 0.05 (or 1.3 when expressed as -log(p-value)) marked by an asterisk. The range of the y-axis was formatted the same to facilitate comparison across all the graphs in the figure.

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Journal of Neuroinflammation

ISSN: 1742-2094