Skip to main content
Figure 5 | Journal of Neuroinflammation

Figure 5

From: Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin

Figure 5

Sarin-induced seizure up-regulates the expression of IL-1β in all five brain regions examined. Tissues were collected at 0.25, 1, 3, 6, and 24 h after seizure onset and processed for oligonucleotide microarray analysis. IL-1β expression peaked at 1 h in the amygdala, hippocampus, and thalamus, while it peaked at 3 h in the septum and at 24 h in the piriform cortex. The expression levels decreased nearer to control level in the hippocampus, septum, and thalamus, while it remained approximately the same in the amygdala. However, IL-1β transcript level was increasing in the piriform cortex at our latest time point of 24 h.

Back to article page