Skip to main content
Figure 7 | Journal of Neuroinflammation

Figure 7

From: Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin

Figure 7

Seizure-induced alteration of inflammatory response, cellular movement, and hematological system development and function gene network. The dataset was filtered on brain region (amygdala, hippocampus, piriform cortex, septum, or thalamus), and a two-way interaction ANOVA was used to identify the genes most significantly altered in each region based on exposure (saline or sarin) and time after seizure onset. The significant genes from each ANOVA (p-value ≤ 0.05) were compared using a Venn diagram, and the top 800 overlapping genes that mapped to canonical pathways in the IPA Knowledge Base were overlaid onto a global molecular network developed from information within the IPA Knowledge Base. The networks were then algorithmically generated based on their connectivity. Genes are represented as nodes of various shapes to represent the functional class of the gene product, and the biological relationship between two nodes is represented as a line. The intensity of the node color indicates the degree of differential expression.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094