Figure 1

LPS administered via the i.c.v . route induces depressive-like behavior. Mice were injected i.c.v. with either PBS or Tat (40 ng). (A) Body weight was measured before and 24 h after injection and expressed as body weigh change. (B) Duration of immobility was quantified during a 5 min forced swim test that took place 24 h following administration of Tat or PBS. Data represent mean ± SEM (n = 6 mice/group). * p < 0.05 compared to PBS.