Figure 2

Preservation of TH-ir fibers in the striatum. Microphotographs of TH immunostained coronal brain sections at the level of the anterior commisure of (A) placebo (B) 2.5 mg/kg and (C) 5 mg/kg pioglitazone-treated hemiparkinsonian monkeys. Scale bar = 10 mm. Note the preservation of TH-ir fibers in the caudate and putamen ipsilateral to MPTP insult in pioglitazone-treated animals. (D) Optical density (OD) of TH immunostaining in the intact and MPTP treated putamen (*ANOVA; P = 0.001).