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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

Figure 3

Preservation of TH-ir cells in the substantia nigra. Microphotographs of TH immunostained coronal brain sections at the level of the substantia nigra of placebo (A, a), 2.5 mg/kg (B, b), and 5 mg/kg (C, c) pioglitazone-treated hemiparkinsonian monkeys. Rectangles in A, B and C indicate the location of high magnification images a, b, c. Scale bar: A, B, C = 1 mm; a, b, c = 325 μm. D: Stereological cell counts showed a significant preservation of TH-ir cells in the substantia nigra ipsilateral to MPTP insult in 5 mg/kg pioglitazone-treated group compared to placebo (*ANOVA; P = 0.02), and higher TH-ir cell count in the intact side of animals treated with 2.5 and 5 mg/kg of pioglitazone compared to placebo (#ANOVA; P = 0.014, P = 0.02).

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