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Figure 2 | Journal of Neuroinflammation

Figure 2

From: TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

Figure 2

TLR4 mutation increased Aβ load in the brain of an AD mouse model at 9 months of age. Aβ plaques in the brains of TLR4W Tg (A and C) and TLR4M Tg (B and D) mice were visualized by 6E10 immunohistochemistry and thioflavin S fluorescence, respectively. Average percentages of areas showing Aβ immunoreactivity and fluorescence in the neocortex (G and I) and hippocampus (H and J) are shown as a bar graph (means ± SEM). Activated microglia were detected by anti-CD11b antibody in TLR4W Tg (E) and TLR4M Tg (F) mice. The inset images (E and F) are a higher magnification of the areas indicated by the squares. Average percentages of CD11b-immunoreactive areas in the neocortex (K) and hippocampus (L) are shown as a bar graph (means ± SEM). The ratio of CD11b-immunoreactive area to 6E10-immunoreactive area in the neocortex (M) and hippocampus (N) are shown as a bar graph (means ± SEM). *P < 0.05. Scale bars 200 μm for A through F and 10 μm for the insets.

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