Figure 3From: TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease TLR4 mutation increased cerebral buffer-soluble Aβ42 in an AD mouse model at 9 months of age. The cerebral buffer-soluble Aβ42 and Aβ40 contents in TLR4W and TLR4M Tg mice were quantified by ELISA. The results are shown as bar graphs (means ± SEM pg/mg total protein). *P < 0.01.Back to article page