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Figure 6 | Journal of Neuroinflammation

Figure 6

From: TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

Figure 6

TLR4 mutation decreased expression levels of IL-1β, CCL3 and CCL4 in an AD mouse model at 9 months of age. mRNA levels of cytokines and chemokines in the neocortex and hippocampus from TLR4W and TLR4M Tg mice at age 5 and 9 months were determined by real-time PCR using cDNA prepared by reverse-transcription of mRNA. mRNA levels of cytokines and chemokines were normalized by subtracting cycle threshold (Ct) values obtained with GAPDH mRNA and are shown as 2 -ΔCt [ΔCt = Ct (cytokine or chemokine) - Ct (GAPDH)] (means ± SEM). *P < 0.05.

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Journal of Neuroinflammation

ISSN: 1742-2094