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Table 2 Multivariate logistic regression for SP type (no SP - reference group, non-neuritic SP and neuritic SP) and association with CRP SNPs (APOE4 carriership and age were included as covariates)

From: CRP gene variation affects early development of Alzheimer's disease-related plaques

     

Non-Neuritic SP

Neuritic SP

  

Assoc.

Total

Prev %

Affected (%)

OR

CI

p

Affected (%)

OR

CI

p

rs2794521

TT*

T allele

- high

321

60.8

36

11.2

1

Ref

-

68

21.2

1

Ref

-

 

CC

 

25

4.7

2

8.0

0.673

0.142 - 3.200

0.619

8

32.0

1.265

0.410 - 2.272

0.683

 

CT

 

182

34.5

13

7.1

0.433

0.197 - 0.952

0.037a

26

14.3

0.600

0.317 - 1.138

0.118

rs3091244

CC*

T & A

alleles

- high

179

33.7

18

10.1

1

Ref

-

32

17.9

1

Ref

-

 

TT

 

73

13.7

2

2.7

0.290

0.063 - 1.334

0.112

19

26.0

1.829

0.786 - 4.254

0.161

 

TA

 

16

3.0

5

31.3

6.717

1.673 - 26.978

0.007a

3

18.8

4.535

0.873 - 23.555

0.072

 

CA

 

41

7.7

7

17.1

1.771

0.606 - 5.172

0.296

9

22.0

2.117

0.730 - 6.139

0.167

 

AA

 

3

0.6

0

0

.

.

.

0

0

.

.

0.998

 

TC

 

219

41.2

20

9.1

0.819

0.384 - 1.744

0.604

40

18.3

1.179

0.589 - 2.361

0.642

rs1800947

GG*

C allele

- low

457

86.4

43

9.4

1

Ref

-

89

19.5

1

Ref

-

 

CC

 

5

0.9

1

20.0

7.107

0.419 - 120.535

0.175

2

40.0

3.814

0.160 - 90.798

0.408

 

GC

 

67

12.7

7

10.4

1.428

0.579 - 3.526

0.439

12

17.9

0.700

0.270 - 1.813

0.463

rs1130864

CC*

T allele

- high

220

42.2

25

11.4

1

Ref

-

40

18.2

1

Ref

-

 

TT

 

72

13.8

2

2.8

0.258

0.058 - 1.154

0.076

19

26.4

1.645

0.738 - 3.666

0.224

 

TC

 

229

44.0

24

10.5

0.898

0.461 - 1.748

0.751

43

18.8

1.185

0.630 - 2.229

0.599

rs1205

TT*

C allele

- high

65

12.3

9

13.8

1

Ref

-

12

18.5

1

Ref

-

 

CC

 

224

42.5

15

6.7

0.397

0.154 - 1.025

0.056

51

22.8

1.492

0.584 - 3.814

0.403

 

CT

 

238

45.2

28

11.8

0.675

0.281 - 1.623

0.380

40

16.8

0.949

0.363 - 2.478

0.914

rs3093075

CC*

C allele

- high

469

88.7

39

8.3

1

Ref

-

91

19.4

1

Ref

-

 

AA

 

3

0.6

0

0

.

.

.

0

0

.

.

.

 

CA

 

57

10.8

12

21.1

3.492

1.545 - 7.894

0.003a

12

21.1

2.143

0.914 - 5.022

0.080

  1. * denotes the most common homozygous genotype acting as the reference group in analyses.
  2. . denotes the values were unable to be computed.
  3. adenotes statistically significant values.
  4. Non-neuritic SP are diffuse and primitive SP grouped together, neuritic SP are classic and burnt out SP grouped together; as measured by a neuropathologist.
  5. Prev % refers to prevalence of alleles.
  6. Assoc. refers to associations with CRP levels.
  7. CRP = c-reactive protein gene, SNPs = single nucleotide polymorphisms, SP = senile plaques, OR = odds ratio, CI = confidence interval, p = p value.
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Journal of Neuroinflammation

ISSN: 1742-2094