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Table 2 Multivariate logistic regression for SP type (no SP - reference group, non-neuritic SP and neuritic SP) and association with CRP SNPs (APOE4 carriership and age were included as covariates)

From: CRP gene variation affects early development of Alzheimer's disease-related plaques

      Non-Neuritic SP Neuritic SP
   Assoc. Total Prev % Affected (%) OR CI p Affected (%) OR CI p
rs2794521 TT* T allele
- high
321 60.8 36 11.2 1 Ref - 68 21.2 1 Ref -
  CC   25 4.7 2 8.0 0.673 0.142 - 3.200 0.619 8 32.0 1.265 0.410 - 2.272 0.683
  CT   182 34.5 13 7.1 0.433 0.197 - 0.952 0.037a 26 14.3 0.600 0.317 - 1.138 0.118
rs3091244 CC* T & A
alleles
- high
179 33.7 18 10.1 1 Ref - 32 17.9 1 Ref -
  TT   73 13.7 2 2.7 0.290 0.063 - 1.334 0.112 19 26.0 1.829 0.786 - 4.254 0.161
  TA   16 3.0 5 31.3 6.717 1.673 - 26.978 0.007a 3 18.8 4.535 0.873 - 23.555 0.072
  CA   41 7.7 7 17.1 1.771 0.606 - 5.172 0.296 9 22.0 2.117 0.730 - 6.139 0.167
  AA   3 0.6 0 0 . . . 0 0 . . 0.998
  TC   219 41.2 20 9.1 0.819 0.384 - 1.744 0.604 40 18.3 1.179 0.589 - 2.361 0.642
rs1800947 GG* C allele
- low
457 86.4 43 9.4 1 Ref - 89 19.5 1 Ref -
  CC   5 0.9 1 20.0 7.107 0.419 - 120.535 0.175 2 40.0 3.814 0.160 - 90.798 0.408
  GC   67 12.7 7 10.4 1.428 0.579 - 3.526 0.439 12 17.9 0.700 0.270 - 1.813 0.463
rs1130864 CC* T allele
- high
220 42.2 25 11.4 1 Ref - 40 18.2 1 Ref -
  TT   72 13.8 2 2.8 0.258 0.058 - 1.154 0.076 19 26.4 1.645 0.738 - 3.666 0.224
  TC   229 44.0 24 10.5 0.898 0.461 - 1.748 0.751 43 18.8 1.185 0.630 - 2.229 0.599
rs1205 TT* C allele
- high
65 12.3 9 13.8 1 Ref - 12 18.5 1 Ref -
  CC   224 42.5 15 6.7 0.397 0.154 - 1.025 0.056 51 22.8 1.492 0.584 - 3.814 0.403
  CT   238 45.2 28 11.8 0.675 0.281 - 1.623 0.380 40 16.8 0.949 0.363 - 2.478 0.914
rs3093075 CC* C allele
- high
469 88.7 39 8.3 1 Ref - 91 19.4 1 Ref -
  AA   3 0.6 0 0 . . . 0 0 . . .
  CA   57 10.8 12 21.1 3.492 1.545 - 7.894 0.003a 12 21.1 2.143 0.914 - 5.022 0.080
  1. * denotes the most common homozygous genotype acting as the reference group in analyses.
  2. . denotes the values were unable to be computed.
  3. adenotes statistically significant values.
  4. Non-neuritic SP are diffuse and primitive SP grouped together, neuritic SP are classic and burnt out SP grouped together; as measured by a neuropathologist.
  5. Prev % refers to prevalence of alleles.
  6. Assoc. refers to associations with CRP levels.
  7. CRP = c-reactive protein gene, SNPs = single nucleotide polymorphisms, SP = senile plaques, OR = odds ratio, CI = confidence interval, p = p value.