Table 3 Multivariate logistic regression results for SP type (no SP - reference group, non-neuritic SP and neuritic SP) and association with CRP haplotypes (APOE4 carriership and age were included as covariates)
From: CRP gene variation affects early development of Alzheimer's disease-related plaques
Non-Neuritic SP | Neuritic SP | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Assoc. | Total | Prev % | Affected (%) | OR | CI | p | Affected (%) | OR | CI | p | ||||
TTGTC | Yes* | High-CRP | 306 | 37.0 | 26 | 8.5 | 1 | Ref | - | 62 | 20.3 | 1 | Ref | - |
(1) | No | 225 | 26 | 11.6 | 1.402 | 0.740 - 2.656 | 0.300 | 41 | 18.2 | 0.776 | 0.435 - 1.383 | 0.390 | ||
TCGCC | No* | No assoc. | 516 | 52 | 10.1 | 1 | Ref | - | 96 | 18.6 | 1 | Ref | - | |
(3) | Yes | 15 | 1.2 | 0 | 0.0 | . | . | . | 7 | 46.7 | 4.124 | 0.700 - 24.278 | 0.117 | |
TCGCT | No* | No assoc. | 282 | 22 | 7.8 | 1 | Ref | - | 61 | 21.6 | 1 | Ref | - | |
(4) | Yes | 249 | 30.0 | 30 | 12.0 | 1.397 | 0.736 - 2.651 | 0.307 | 42 | 16.9 | 0.686 | 0.386 - 1.217 | 0.197 | |
TCCCT | No* | Low-CRP in females | 459 | 44 | 9.6 | 1 | Ref | - | 89 | 19.4 | 1 | Ref | - | |
(5) | Yes | 72 | 6.6 | 8 | 11.1 | 1.545 | 0.655 - 3.644 | 0.321 | 14 | 19.4 | 0.775 | 0.312 - 1.923 | 0.582 | |
TAGCC | No* | High-CRP | 471 | 40 | 8.5 | 1 | Ref | - | 91 | 19.3 | 1 | Ref | - | |
(6) | Yes | 60 | 5.2 | 12 | 20.0 | 2.985 | 1.342 - 6.638 | 0.007a | 12 | 20.0 | 1.809 | 0.785 - 4.167 | 0.164 | |
CCGCC | No* | Low-CRP in males | 324 | 37 | 11.4 | 1 | Ref | - | 69 | 21.3 | 1 | Ref | - | |
(7) | Yes | 207 | 19.5 | 15 | 7.2 | 0.453 | 0.218 - 0.941 | 0.034a | 34 | 16.4 | 0.680 | 0.376 - 1.228 | 0.201 | |