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Table 4 Results validated by FDR < 0.05 cutoff limit

From: CRP gene variation affects early development of Alzheimer's disease-related plaques

p-value

SNP (and genotype) or Haplotype

Association

p< 0.0001

n/a

Aβ IHC and CRP IHC stainings (Chi square)

p = 0.003

rs3093075 (genotype CA)

Increased risk of non-neuritic SP

p = 0.007

rs3091244 (TA)

Increased risk of non-neuritic SP

p = 0.007

Haplotype (6) TAGCC

Increased risk of non-neuritic SP

p = 0.037

rs2794521 (CT)

Reduced risk of non-neuritic SP

p = 0.076

rs1130864 (TT)

Reduced risk of non-neuritic SP

p = 0.076

Haplotype (4) TCGCT

Reduced risk of having NFT

p = 0.080

rs3093075 (CA)

Increased risk of neuritic SP

p = 0.083

rs2794521 (CT)

More likely to have CRP IHC staining

p = 0.087

rs3093075 (CA)

Less likely to have CRP IHC staining

p = 0.090

Haplotype (6) TAGCC

Less likely to have CRP IHC staining

p = 0.112

rs3091244 (TT)

Reduced risk of non-neuritic SP

p = 0.118

rs2794521 (CT)

Reduced risk of neuritic SP