Effects of i.p. injection of LPS on behavioral performances at 10 months post-treatment. (A) Mean time spent in the open and close arms by the animals in Elevated Plus Maze is depicted. (B) Total distance (1), peripheral distance (2), central crossings (3), mean contact times with objects during habituation phase (S2-S4) (4), spatial change (5), and novelty (6) exhibited by the two experimental groups in Open Field with Objects are depicted. (C) Mean escape latencies to reach the platform (1), navigational strategies (2), and time spent in the rewarded quadrant (3) displayed by the two experimental groups in Morris Water Maze are depicted. In this figure, the circular figurines illustrate the typical explorative patterns of the five navigational strategies (C, Circling; ES, Extended Searching; RS, Restricted Searching; RC, Restricted Circling; F, direct Finding). Asterisks inside the graphs indicate the significance of comparisons between groups: * P <0.05, *** P ≤0.001.