Figure 5

Effects of i.p. injection of LPS on brain regional expression of cytokines at 10 months post treatment. The levels of TNF-α (upper row of panels) and IL-18 (lower row of panels) in LPS-treated (LPS, black bar) and PBS-injected control animals (CTR, open bar) were assessed 10 months post-treatment by using specific ELISA, as described in the Materials and methods section. Results are reported as histograms representing the cytokine mean concentrations with SEM error bars for each dissected brain region. Values measured from each group of rats (n = 6) were calibrated by tissue weight. Asterisks inside the graphs indicate the significance of comparisons between groups: * P <0.05, ** P <0.01, *** P <0.001.