Figure 4

IL-17 mediates mortality, independent of CNS neutrophil infiltration. (A) Survival was assessed daily in infected SCID recipients of WT (n = 8), WT + anti-IL-17 mAb (n = 12), GKO (n = 8) and GKO + anti-IL-17 mAb (n = 12) CD4⁺ T cells until day 18 p.i. Data are mean from two separate experiments (B) Total numbers of neutrophils determined by flow cytometry at day eight p.i. in infected SCID recipients of WT, WT + anti-IL-17 mAb, GKO, GKO + anti-IL-17 mAb CD4⁺ T cells. Data represent the mean from two independent experiments (n = 4, untreated mice and n = 8, anti-IL-17-treated mice per experiment).