Skip to main content
Figure 5 | Journal of Neuroinflammation

Figure 5

From: Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

Figure 5

3,6′-Dithiothalidomide (56 mg/kg i.p.) treatment reduces the activation of astrocyte cells induced by the intercerebroventricular administration of LPS. Representative images of GFAP + ve cells in a field of view of the granule cell layer of the hippocampus are shown. The upper left panel (×20 objective magnification for both treatments) illustrates the highly activated numbers and morphology of astrocytes after the administration of LPS; the smaller image is a higher magnification of a section from the same image (×63 objective magnification, for both treatments). The lower panel illustrates how drug treatment markedly reduces the activated morphology of astrocytes after treatment with LPS; similarly to the above, this effect is further illustrated in the higher magnification side image. Astrocytes are stained red, whereas nuclei are counterstained green.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094