Figure 1

Aβ modulates CD200R-associated signaling. A. Incubation of purified astrocytes in the presence of Aβ decreased CD200 expression as illustrated in the sample immunoblot and in the densitometric data (**P < 0.01; Student’s t-test for independent means; n = 6). B and C. Aβ significantly increased CD200R mRNA on purified microglia (B) and the percentage of CD200R⁺ CD11b⁺ cells (C; *P < 0.05; **P < 0.01; Student’s t-test for independent means; n = 6). D and E. Whereas Aβ decreased Dok2 phosphorylation (D), CD200Fc increased its phosphorylation in a time-dependent manner (E).