Figure 2
From: Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia
CD200Fc attenuated the Aβ-induced increases in markers of microglial activation. Incubation of mixed glia in the presence of Aβ significantly increased expression of CD68 mRNA (A) and CD40 mRNA (C; **P < 0.01; ***P < 0.001; ANOVA; n = 6). Aβ also increased the percentage of CD11b+ cells which expressed CD68 (B) and CD40 (D; ***P < 0.001; ANOVA; n = 6). Addition of CD200Fc to the incubation medium significantly attenuated the Aβ-induced changes in CD68 mRNA, CD40 mRNA and the percentage of CD11b+ cells which expressed CD40 (+ P < 0.05; ++ P < 0.01; +++ P < 0.001).