Figure 4

CD200Fc attenuated the Aβ-induced increases in IL-1β and TNFα. Incubation of mixed glia in the presence of Aβ significantly increased expression of IL-1β mRNA (A) and TNFα mRNA (C; ***P < 0.001; ANOVA; n = 6). Aβ also increased supernatant concentrations of IL-1β (B) and TNFα (D; *P < 0.05; ***P < 0.001; ANOVA; n = 6). Addition of CD200Fc to the incubation medium significantly attenuated the Aβ-induced changes in these four parameters (⁺ P < 0.05; ⁺⁺ P < 0.01; ⁺⁺⁺ P < 0.001).