Figure 7
Schematic overview of the results from the present study indicating WNT-5A secretion from astrocytes and the WNT-5A-induced signaling pathway towards ERK1/2 regulating distinct aspects of the proinflammatory transformation of microglia. Pharmacological inhibitors used in the study: D4476, pertussis toxin (PTX), M119, BAPTA-AM, U73122, bisindolaleiimide (BIS), SL327. Abbreviations: AC, adenylyl cyclase; cAMP, cyclic AMP; DAG, diacylglycerol; DVL, disheveled; ERK1/2, extracellular signal-regulated kinases 1/2; FZD, Frizzled; IP3, inositoltriphosphate; MEK1/2, MAPK/ERK kinase 1/2; MMP, matrix metalloprotease; PLC, phospholipase C; PKC, Ca2+-dependent protein kinase; Gi, heterotrimeric G proteins of the Gi/o family; WNT, Wingless/int-1.