Table 1 Inhibition of MEK1/2 by SL327 blocks WNT-5A-induced expression of matrix metalloproteases.
Gene | WNT-5A | WNT-5A/SL327 | Ratio |
|---|---|---|---|
IL1β | 209.8 ± 78.2 | 88.1 ± 16.3 | 0.4 |
IL6 | 947.0 ± 554.4 | 541.0 ± 175.8 | 0.6 |
IL12 | 33622.0 ± 26855.0 | 31504.0 ± 14202.0 | 0.9 |
TNFα | 43.0 ± 5.7 | 366.3 ± 84.5** | 8.5 |
CCL7 | 29.1 ± 5.1 | 574.7 ± 348.2* | 19.7 |
CCL12 | 26.7 ± 7.0 | 354.7 ± 206.3** | 12.9 |
COX-2 | 93.3 ± 30.4 | 448.3 ± 169.9* | 4.8 |
CD40 | 558.0 ± 133.0 | 1989.0 ± 398.0** | 3.6 |
CD69 | 456.0 ± 155.0 | 1723.0 ± 606.0 | 3.8 |
MMP9 | 5.1 ± 1.2 | 1.0 ± 0.1* | 0.2 |
MMP13 | 28.3 ± 8.0 | 6.7 ± 0.9** | 0.2 |