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Table 1 Inhibition of MEK1/2 by SL327 blocks WNT-5A-induced expression of matrix metalloproteases.

From: Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

Gene WNT-5A WNT-5A/SL327 Ratio
IL1β 209.8 ± 78.2 88.1 ± 16.3 0.4
IL6 947.0 ± 554.4 541.0 ± 175.8 0.6
IL12 33622.0 ± 26855.0 31504.0 ± 14202.0 0.9
TNFα 43.0 ± 5.7 366.3 ± 84.5** 8.5
CCL7 29.1 ± 5.1 574.7 ± 348.2* 19.7
CCL12 26.7 ± 7.0 354.7 ± 206.3** 12.9
COX-2 93.3 ± 30.4 448.3 ± 169.9* 4.8
CD40 558.0 ± 133.0 1989.0 ± 398.0** 3.6
CD69 456.0 ± 155.0 1723.0 ± 606.0 3.8
MMP9 5.1 ± 1.2 1.0 ± 0.1* 0.2
MMP13 28.3 ± 8.0 6.7 ± 0.9** 0.2