A: Differences in blood flow reduction in the striatum of anesthetized WKYRs and SHRs. Shown are differences in blood flow reduction in the striatum of anesthetized WKYRs and SHRs after administration of 400 pmol Et-1. There were no differences between the two strains. *Significantly different from baseline levels. Differences between SHR and WKY were not significant for all time points as assessed by the unpaired Student’s t-test. (n = 4 for every group). B: Fixed fields in the striatum and cortex used for assessment of CD68 and GFAP expression. The three fixed fields are indicated in the striatum. Each has an area of 1 mm2. Cells are counted in the three separate fields and the results are expressed as mean number of cells/mm2. For the cortex, cells are counted between the reference lines. To determine the level of GFAP expression, the relative intensity is measured in the whole striatum and in the cortical region between the reference lines.