Figure 6

CD68 (A-C) and Iba-1 expression levels (D-H) in WKYRs and SHRs 24 hrs after injection of LPS. The expression of CD68 is shown in a micrograph taken from a representative region in the striatum from WKYRs (A) and SHRs (B) and quantitative results are presented in the graph C. (The number of animals per group were n = 3 for the sham WKYRs and n = 4 for the sham SHRs; n = 4 for the LPS-treated groups). The expression of Iba-1 is shown for the ipsilateral (D, E) and contralateral hemispheres (F, G) for WKYRs (D, F) and SHRs (E, G). Graph H depicts quantitative differences in Iba-1 expression in the striatum of WKYRs and SHRs at 24 h after injection of 2 μg LPS (n = 4 for the all groups). *Significant difference between WKYRs and SHRs. ^$ Significant difference between sham and Et-1 treated animals. ns, no significant difference between WKYRs and SHRs. Scale bar A, B = 50 μm; scale bar D-G = 50 μm, scale bar insert = 20 μm.