Figure 6

Dasatinib infusion reduced CD68 and TNF-α protein levels in APP/PS1 brains. (A) Hippocampal and (B) temporal cortex brain lysates from control, vehicle, and dasatinib infused animals were Western blotted for activated microglia using anti-CD68 antibody and anti-pro-inflammatory cytokine TNF-α antibody along with anti-α-tubulin as a loading control. Optical densities were averaged and graphed (+/−SEM) from blots of (C) hippocampus (**P <0.01 from controls) and (D) temporal cortex (*P <0.05 from controls).