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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer’s disease

Figure 7

Dasatinib infusion did not alter levels of APP, Aβ, synaptophysin, PSD95, or GFAP levels in APP/PS1 brains. (A) Hippocampal and (B) temporal cortex brain lysates from control, vehicle, and dasatinib infused animals were used for Western blot analyses using anti-Aβ clone 6E10 antibody, anti-APP, anti-synaptophysin, anti-PSD95, anti-GFAP, anti-α-tubulin and βIII tubulin (loading control) antibodies. Optical densities for each antibody were normalized to tubulin loading controls, averaged, and graphed (+/−SEM) for (C) hippocampus and (D) temporal cortex.

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