Figure 7
From: Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
Functional analysis of global gene expression in nerves and spinal cords after intraneural MBP84-104 injection. Ingenuity pathway analysis of the gene expression used as the input list for generation of the top functional categories and canonical pathways (X-axis). The bars represent -log10 (P value) for a function or a pathway to be represented with a threshold (dashed line) set at 1.3 (P <0.05) in n = 6/group (right-tailed Fisher's exact test). Biological functions and canonical pathways are listed from most to least significant in the experimental MBP-injected animals in the injected compared to control contralateral sciatic nerves (A, B) or in the dorsal horns of the corresponding lumbar compared to control thoracic spinal cords (C, D) of the same animals. LXR, liver X receptor; RXR, retinoid X receptor; VDR, vitamin D receptor.