Skip to main content

Table 3 MBP84-104 activates inflammatory pathways in nerve

From: Immunodominant fragments of myelin basic protein initiate T cell-dependent pain

Functions annotation

Nerve, -log (P value)

Spinal cord, -log (P value)

WT

Nude

WT

Nude

Immune response

20.2

-

4.32

-

Inflammatory response

15.8

-

2.79

1.42

Activation of T lymphocytes

7.8

-

2.64

-

Chemotaxis/aggregation of APCs

5.5

2.39

2.54

2.88

Chemotaxis of monocytes

4.2

2.61

1.86

2.36

  1. Ingenuity pathway analysis of the genome 1 week after the MBP84-104 injection into the intact sciatic nerve in the wild-type and nude rats. Up-regulated functions as a result of inflammatory response in the injected nerve compared to the contralateral sciatic nerve and in the lumbar compared to the thoracic spinal cord, dorsal horn, are shown. Cutoff is set at P < 0.05 (−log10 > 1.3). Minus indicates that the Ingenuity software did not detect the presence of the pathway in the sample.