Figure 3

Immunohistology analysis of spinal cord lesions in EAE-induced SRA ^−/− and WT mice. Spinal cord sections from WT and SRA^−/− EAE-induced mice (n = 5) were stained, and the fluorescent signals were detected using an Odyssey scanner. (A) Representative images of GFAP, an astrocyte marker, and Iba1, a microglia/macrophage marker. (B) There was a reduction in signal intensity of GFAP and Iba1 stained SRA^−/− sections as compared to WT. Statistical analysis was performed using Student’s t-test. Results are presented as means ± SEM.