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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression

Figure 1

RT-PCR analysis and western blot analysis of Nogo-A mRNA and protein production in the hippocampus after TBI. (A) The PCR products from Nogo-A transcription after TBI with the yield of actin as an internal control. The sampling times after TBI are shown on the top (n = 4 in each group). (B) Quantification of Nogo-A mRNA expression by semiquantitative densitometry in conjunction with AlphaEase software (Alpha Innotech Corp.). (C) Time course of Nogo-A protein production after TBI, internal control: β-actin. Times shown on top represent hours after injury. (D) Quantification of Nogo-A protein by semiquantitative densitometry in conjunction with AlphaEase software (Alpha Innotech Corp.). The data are presented as ratios related to the sham group. Bars represent the means ± SEM values. *p < 0.05 is considered significantly different from sham values using the Mann–Whitney U test. SEM, standard error of the mean; TBI, traumatic brain injury.

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Journal of Neuroinflammation

ISSN: 1742-2094