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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression

Figure 2

Effects of Nogo-A irrelevant control and antisense oligodeoxynucleotides on hippocampal Nogo-A expression after TBI. (A) RT-PCR analysis of Nogo-A mRNA transcription level. Actin transcription was used as an internal control. (B) The expression of Nogo-A was quantified by densitometry and compared with the data from rats injected with saline (sham), which was normalized to 100%. (C) Western blot analysis of Nogo-A protein level; β-actin was used as an internal control. (D) Quantification of Nogo-A protein by semiquantitative densitometry in conjunction with AlphaEase software (Alpha Innotech Corp.). The data are presented compared with the sham group. The data are represented as the means ± SEM values (n = 6). *p < 0.05 was considered significantly different from the sham value using the Mann-Whiney U test, and # p < 0.05 was considered significantly different from the TBI with sense values using the Mann-Whiney U test. SEM, standard error of the mean; TBI, traumatic brain injury.

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Journal of Neuroinflammation

ISSN: 1742-2094