Figure 5
From: LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner
Schematic representation of LPS-induced signaling and cytokine release. Toll-like receptor (TLR)4 is stimulated by LPS and triggers activation of MAPKs and NFkB (1) which results in release of TNFα and IL-1β (2). Released TNFα interacts with its receptor (3), activating JAK2 and STAT1 (4) which up-regulates transcription and release of IL-6 (5). IL-6 feeds back to inhibit further release of TNFα and IL-1β (6), limiting the inflammatory changes.