Skip to main content
Figure 3 | Journal of Neuroinflammation

Figure 3

From: Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model

Figure 3

Pharmacologic blockade of 5-lipoxygenase activating protein reduces neuroinflammation. (A, C) Representative brain sections of the cortex region from Tg2576 receiving MK-591 or vehicle (control) immunostained for CD45 and GFAP (× 20 magnification). (B, D) Quantitative analysis of the immunoreactivity for CD45 and GFAP in the same animals. (E) Representative western blot analysis of GFAP and 5-LO in brain homogenates of Tg2576 receiving MK-591 or control. (F) Densitometric analysis of the immunoreactivities to the antibodies shown in the previous panel. (G) Levels of IL-1β in brain homogenates of Tg2576 mice receiving MK-591 or controls (n = 8 controls, n = 10 MK-591;*P = 0.01). CD45: cluster of differentiation 45; GFAP: glial acidic fibrillary protein; 5-LO: 5-lipoxygenase.

Back to article page