Figure 7

IL-17 receptor signaling differentially regulates natural killer T (NKT) and gamma-delta (γδ) T cell recruitment into brain abscesses. Abscess-associated cells from IL-17 receptor (IL-17R) knockout (KO) and wild-type (WT) mice (n = 5 to 9 per group) were recovered at the indicated time points after infection and analyzed by flow cytometry to identify NKT (NK1.1⁺/NKp46^-; red) and gamma-delta (γδ) T cells (γδTCR⁺; green). Fluorescence-activated cell sorting (FACS) contour plots are presented to demonstrate the different population densities and distributions between IL-17R KO and WT mice at days 7 (a) and 14 (b). These populations were quantified and results presented as the absolute cell number of each population at days 7 (c) and 14 (d) following infection from a total of four independent experiments (mean ± SD). *P < 0.05, significant differences in abscess-associated T cell subsets between IL-17R KO and WT mice.