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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

Figure 3

BBB changes in cerebral cortex of WT and ApoE−/− mice. A) Age dependent blood brain barrier impairment in ApoE−/− mice. Quantification of IgG leakage in brain sections stained with anti-IgG antibody (n = 7 to 9 per group). Each column represents mean ± SEM. # P <0.05 young ApoE−/− mice vs old ApoE−/− mice and P <0.05 old WT mice vs old ApoE−/− mice. B) Claudin 5 staining (arrow heads) along the cortical blood vessels in the old WT and ApoE−/− mice. The lumen is marked with a star. Claudin 5 staining is decreased in old ApoE−/− mice. C) Quantification of the intensity of the Claudin 5 immunoreactivity (IR) in cortical layers of young and old WT and ApoE−/− mice. Each column represents mean ± SEM (n = 4 per group). * P <0.05 young ApoE−/− mice vs old ApoE−/− mice.

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