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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain

Figure 3

The expression of CCL2 in the MDH following IAMNT. (A) Temporal changes of CCL2-IR in the MDH following IAMNT at the level of 300 μm caudal to the obex. The area where the pictures were taken was shown in (a). CCL2-IR was very mild in naïve mice (b), but increased at 3 days (e), 10 days (f), and 21 days (g). CCL2-IR was also mild in the sham-operated mice (c). Scale bar, 50 μm. (B) Spatial changes of CCL2-IR in the MDH at 10 days after IAMNT. CCL2 expression was increased from 300 μm rostral to the obex (a) to 1500 μm caudal to the obex (g) in the ipsilateral side. However, no obvious change of CCL2 expression was found in the contralateral side of the MDH. Scale bar, 100 μm.

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