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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain

Figure 7

The expression and cellular distribution of CCR2 in the MDH. (A) A representative western blot shows CCR2 expression was increased in the ipsilateral medulla after IAMNT. (B) Density of CCR2 band, which is normalized to GAPDH loading control and expressed as ratio of naïve group. * P < 0.05, ** P < 0.01, compared to naïve. ++ P <0.01 compared to sham-operated group. n = 3 for each group. (C) Double staining of CCR2 with different cellular markers. CCR2 is colocalized with neuronal marker, NeuN (a–c), astrocytic marker GFAP (d–f), but not with microglial marker Iba-1 (g–i). Scale bar, 25 μm.

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