Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

Table 2 Summary of selected genes with neuroprotective functions found up-regulated with microarrays in MOG-DNA-treated mice

Affymetrix probe set	Genes	Description	Gene ID^a	FC^b	I-value
Neurotrophic factors
10595050	Gfral	GDNF family receptor alpha like	404194	1.37	0.0186
10416340	Gfra2	GDNF family receptor alpha 2	14586	1.34	0.0030
10487787	Gfra4	GDNF family receptor alpha 4	14588	1.40	0.0475
10552938	Ntf5	Neurotrophin 5	78405	1.29	0.0212
10474399	Bdnf	Brain-derived neurotrophic factor	12064	1.38	0.0487
Remyelination
10596747	Sema3f	Semaphorin 3 F	20350	1.32	0.0133
10526880	Pdgfa	Platelet-derived growth factor, alpha	18590	1.41	0.0389

Differentially expressed genes obtained with microarrays between MOG-DNA-treated mice (n = 5) and control plasmid-treated mice (n = 5) were estimated using Student’s t test, as described in Methods.
^aRefers to Entrez gene ID.
^bFold change expression in MOG-DNA-treated mice versus control plasmid-treated mice. Data represent the mean ratio of five arrays. GDNF: glial cell line derived neurotrophic factor.

ISSN: 1742-2094