Skip to main content

Table 2 Summary of selected genes with neuroprotective functions found up-regulated with microarrays in MOG-DNA-treated mice

From: Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

Affymetrix probe set Genes Description Gene IDa FCb I-value
Neurotrophic factors
10595050 Gfral GDNF family receptor alpha like 404194 1.37 0.0186
10416340 Gfra2 GDNF family receptor alpha 2 14586 1.34 0.0030
10487787 Gfra4 GDNF family receptor alpha 4 14588 1.40 0.0475
10552938 Ntf5 Neurotrophin 5 78405 1.29 0.0212
10474399 Bdnf Brain-derived neurotrophic factor 12064 1.38 0.0487
Remyelination
10596747 Sema3f Semaphorin 3 F 20350 1.32 0.0133
10526880 Pdgfa Platelet-derived growth factor, alpha 18590 1.41 0.0389
  1. Differentially expressed genes obtained with microarrays between MOG-DNA-treated mice (n = 5) and control plasmid-treated mice (n = 5) were estimated using Student’s t test, as described in Methods.
  2. aRefers to Entrez gene ID.
  3. bFold change expression in MOG-DNA-treated mice versus control plasmid-treated mice. Data represent the mean ratio of five arrays. GDNF: glial cell line derived neurotrophic factor.