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Table 1 Comparison of demographic features according to the patients' AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Seropositive Seronegative p-level
Sex ratio (male:female)    
   All patients 1:10.4; N = 137 1:1.9; N = 38 p < 0.0003
Patients meeting Wingerchuk's 2006 criteria 1:9.2; N = 92 1:2; N = 27 p < 0.006
Age at onset (median, range; N)    
   All patients 40 (10-81; N = 137) 38.5 (14-67; N = 38) n.s.§
Patients meeting Wingerchuk's 2006 criteria 36 (10-79; N = 92) 37 (14-63; N = 27) n.s.§
Cases of death, attack-related 5/137 (3.6%)° 0/38 (0%) n.s.
  1. °See results section for causes of death. Four additional patients died from non-attack related causes: One developed sepsis following plasma exchange; another patient with a history of autonomic dysfunction with bradycardia and recent femoral vein thrombosis died from cardiovascular failure 3 days after the second infusion with rituximab [80]; one patient died from voluntary refusal of nutrition and hydration after a severe attack of cervical myelitis that had left her tetraplegic; and one died from an accident. Fisher's exact test (2-tailed). §Mann Whitney U test. N = number of patients; n.s. = not significant.