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Table 10 Frequency of supratentorial and infratentorial brain involvement.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Seropositive (No of patients, %) Seronegative (No of patients, %) p-level
Supratentorial brain lesions at first MRI    
   Total cohort 63/133 (47.4%) 16/35 (45.7%) n.s.
Patients meeting Wingerchuk's 2006 criteria 38/89 (42.7%) 13/26 (50%) n.s.
Supratentorial brain lesions ever    
   Total cohort 78/133 (58.7%) 21/36 (58.3%) n.s.
Patients meeting Wingerchuk's 2006 criteria 51/89 (57.3%) 16/27 (59.3%) n.s.
Brain stem involvement#    n.s.
   Total cohort 39/137 (28.5%) 7/38 (18.4%) n.s.
Patients meeting Wingerchuk's 2006 criteria 31/137 (22.6%) 7/38 (18.4%) n.s.
  1. Considered "compatible with MS" by the reading radiologists in 11 cases (8.9%) in the seropositive group and in 3 cases (9.4%) in the seronegative group (p = n.s.). #Clinical and/or MRI evidence. Fisher's exact test (2-tailed).