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Table 2 Symptoms at disease onset.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

 

Seropositive

Seronegative

p-level

ON at onset

   

   Total cohort

61/135 (45.2%)

14/38 (36.8%)

n.s.‡

Patients meeting Wingerchuk's 2006

criteria

56/90 (62.2%)

12/27 (44.4%)

n.s.‡

MY at onset

   

   Total cohort

64/135 (47.4%)

14/38 (36.8%)

n.s.‡

Patients meeting Wingerchuk's 2006

criteria

24/90 (26.7%)

5/27 (18.5%)

n.s.‡

BSTE at onset

   

   Total cohort

4/135 (3%)

1/38 (2.6%)

n.s.‡

Patients meeting Wingerchuk's 2006

criteria

4/90 (4.4%)

1/27 (3.7%)

n.s.‡

Simultaneous MY and ON at onset

   

   Total cohort

6/135 (4.4%)

9/38 (23.7%)

p < 0.001‡

Patients meeting Wingerchuk's 2006

criteria

6/90 (6.7%)

9/27 (33.3%)

p < 0.013‡

Bilateral ON at onset

   

   All patients with a history of ON

9/63 (14.3%)

9/22 (40.9%)

p < 0.015‡

Patients meeting Wingerchuk's 2006

criteria

9/59 (15.3%)

8/20 (40%)

p < 0.029‡

  1. Data are not available for 2/175 patients. ‡Fisher's exact test (2-tailed). BSTE = brain stem encephalitis; MY = myelitis; n.s. = not significant; ON = optic neuritis.