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Table 2 Symptoms at disease onset.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Seropositive Seronegative p-level
ON at onset    
   Total cohort 61/135 (45.2%) 14/38 (36.8%) n.s.
Patients meeting Wingerchuk's 2006 criteria 56/90 (62.2%) 12/27 (44.4%) n.s.
MY at onset    
   Total cohort 64/135 (47.4%) 14/38 (36.8%) n.s.
Patients meeting Wingerchuk's 2006 criteria 24/90 (26.7%) 5/27 (18.5%) n.s.
BSTE at onset    
   Total cohort 4/135 (3%) 1/38 (2.6%) n.s.
Patients meeting Wingerchuk's 2006 criteria 4/90 (4.4%) 1/27 (3.7%) n.s.
Simultaneous MY and ON at onset    
   Total cohort 6/135 (4.4%) 9/38 (23.7%) p < 0.001
Patients meeting Wingerchuk's 2006 criteria 6/90 (6.7%) 9/27 (33.3%) p < 0.013
Bilateral ON at onset    
   All patients with a history of ON 9/63 (14.3%) 9/22 (40.9%) p < 0.015
Patients meeting Wingerchuk's 2006 criteria 9/59 (15.3%) 8/20 (40%) p < 0.029
  1. Data are not available for 2/175 patients. Fisher's exact test (2-tailed). BSTE = brain stem encephalitis; MY = myelitis; n.s. = not significant; ON = optic neuritis.