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Table 3 Comparison of clinical features according the patients' AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

 

Seropositive

Seronegative

p-level

Relapsing course

   

   Total cohort

127/137 (92.7%)

29/38 (76.3%)

p < 0.008‡

Patients meeting Wingerchuk's 2006

criteria

92/92 (100%)

22/27 (81.5%)

p < 0.0005‡

Relapse ratio, ON/MY*

0.85; N = 86

1; N = 25

n.s.§

Signs of-existing autoimmunity

   

   Total cohort

76/130 (58.5%)

3/35 (8.6%)

p < 0.00001‡

Patients meeting Wingerchuk's 2006

Criteria

48/86 (55.8%)

3/25 (12%)

P < 0.00009‡

   Co-existing autoimmune disorders†

31/130 (23.8%)

2/35 (5.7%)

p < 0.017‡

   Co-existing auto-antibodies only††

45/97(46.4%)

1/30 (3.3%)

p < 0.00001‡

CSF-restricted OCB at first LP

   

   All patients

30/110 (27.9%)

12/34 (35.3%)

n.s.‡

Patients meeting Wingerchuk's 2006

criteria

19/74 (25.7%)

10/26 (38.5%)

n.s.‡

Median CSF white cell count at first LP

   

   All patients

7 (0-750; N = 106)

7.5 (0-220; N = 30)

n.s.§

Patients meeting Wingerchuk's 2006

Criteria

7.5 (0-750; N = 68)

9 (1-220; N = 23)

n.s.§

Preceding infections at least once#

27/92 (29.3%)

5/28 (17.9%)

n.s.‡

Time to diagnosis of NMO (months)

 

11 (0-255; N = 29)

p < 0.029§

  1. *Only patients with a history of both ON and MY are considered (all meeting Wingerchuk's 2006 criteria). † Diagnoses included autoimmune thyroiditis (N = 10), systemic lupus erythematosus (8), acetylcholine receptor-antibody positive myasthenia gravis (4) [74], cutaneous lupus erythematosus, Sjögren's syndrome, mixed connective tissue disorder, anti-phospholipid antibody syndrome, celiac disease, psoriasis, bullous pemphigoid, pyoderma gangrenosum, vitiligo, atopic dermatitis, sarcoidosis, HLAB27 positive ankylosing spondylitis with sacroileitis, heparin-induced thrombocytopenia, and rheumatoid arthritis. ††In the absence of an established autoimmune disorder; including anti-nuclear antibodies (counted only if ≥ 1:240), antibodies to double stranded DNA, antibodies to single stranded DNA, anti-histone antibodies, anti-centromere antibodies, anti-Scl70 antibodies, anti-SS/A antibodies, anti-SS/B antibodies, anti-phospholipid antibodies, MPO-specific perinuclear antineutrophil cytoplasmic antibodies (pANCA), lactoferrin-specific pANCA, pANCA of unknown specificity, thyroid peroxidase antibodies, anti-mitochondrial antibodies, anti-smooth muscle antibodies, and rheumatoid factor. #Preceding the first attack or preceding relapse at least once. ‡Fisher's exact test (2-tailed). §Mann Whitney U test. CSF = cerebrospinal fluid; LP = lumbar puncture; MY = myelitis; N = number of patients (not all data were available from all patients); n.s. = not significant; OCB = oligoclonal bands; ON = optic neuritis; WCC = white cell count.
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Journal of Neuroinflammation

ISSN: 1742-2094