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Table 7 Myelitis, comparison of clinical features according to the patients' AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

 

Seropositive

Seronegative

p-level

Annualized myelitis attack rate†

   

   All patients with a history of myelitis

0.6 (0.03-3.21; N = 108)

0.47 (0.04-2.88; N = 27)

n.s.§

Patients meeting Wingerchuk's 2006

Criteria

0.51 (0.03-2.73; N = 81)

0.39 (0.09-2.88; N = 20)

n.s.§

Motor symptoms, first myelitis§

   

   All patients with a history of myelitis

78/120 (65%)

22/35 (62.9%)

n.s.‡

Patients meeting Wingerchuk's 2006

Criteria

53/81 (65.4%)

17/27 (63%)

n.s.‡

Motor symptoms, all attacks§

   

   All patients with a history of myelitis

293/409 (71.6%)

54/91 (59.3%)

p < 0.024‡

Patients meeting Wingerchuk's 2006

Criteria

226/304 (74.3%)

42/74 (56.8%)

p < 0.005‡

MRC grade during motor attack*

   

   All patients with a history of myelitis

2 (0-5; N = 82)

3 (0-5; N = 24)

p < 0.013§

Patients meeting Wingerchuk's 2006

Criteria

2 (0-4.5; N = 55)

3.5 (0-5; N = 18)

p < 0.006§

Motor attacks with MRC ≤ 2

   

   All patients with a history of myelitis

88/159 (55.3%)

16/48 (33.3%)

p < 0.009‡

Patients meeting Wingerchuk's 2006

Criteria

71/119 (59.7%)

11/33 (33.3%)

p < 0.01‡

Attacks with complete recovery

   

   All patients with a history of myelitis

55/298 (18.5%)

7/61 (11.5%)

n.s.‡

Patients meeting Wingerchuk's 2006

Criteria

36/223 (16.1%)

6/49 (12.2%)

n.s.‡

  1. †Only patients with a disease duration > = 12 months were considered. *Median (range), calculated based on the patients' individual median MRC grades during all documented motor attacks. ‡ Fisher's exact test (2-tailed). §Mann Whitney U test. §Based on 500 myelitis attacks with either (sensori)motor or sensory symptoms; 3 further documented attacks were only associated with other symptoms such as bladder/bowel dysfunction or spasticity and were therefore not included in the analysis. MRC = Medical Research Council; MY = myelitis; N = number of patients (not all data were available from all patients); n.s. = not significant.