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Table 7 Myelitis, comparison of clinical features according to the patients' AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Seropositive Seronegative p-level
Annualized myelitis attack rate    
   All patients with a history of myelitis 0.6 (0.03-3.21; N = 108) 0.47 (0.04-2.88; N = 27) n.s.§
Patients meeting Wingerchuk's 2006 Criteria 0.51 (0.03-2.73; N = 81) 0.39 (0.09-2.88; N = 20) n.s.§
Motor symptoms, first myelitis§    
   All patients with a history of myelitis 78/120 (65%) 22/35 (62.9%) n.s.
Patients meeting Wingerchuk's 2006 Criteria 53/81 (65.4%) 17/27 (63%) n.s.
Motor symptoms, all attacks§    
   All patients with a history of myelitis 293/409 (71.6%) 54/91 (59.3%) p < 0.024
Patients meeting Wingerchuk's 2006 Criteria 226/304 (74.3%) 42/74 (56.8%) p < 0.005
MRC grade during motor attack*    
   All patients with a history of myelitis 2 (0-5; N = 82) 3 (0-5; N = 24) p < 0.013§
Patients meeting Wingerchuk's 2006 Criteria 2 (0-4.5; N = 55) 3.5 (0-5; N = 18) p < 0.006§
Motor attacks with MRC ≤ 2    
   All patients with a history of myelitis 88/159 (55.3%) 16/48 (33.3%) p < 0.009
Patients meeting Wingerchuk's 2006 Criteria 71/119 (59.7%) 11/33 (33.3%) p < 0.01
Attacks with complete recovery    
   All patients with a history of myelitis 55/298 (18.5%) 7/61 (11.5%) n.s.
Patients meeting Wingerchuk's 2006 Criteria 36/223 (16.1%) 6/49 (12.2%) n.s.
  1. Only patients with a disease duration > = 12 months were considered. *Median (range), calculated based on the patients' individual median MRC grades during all documented motor attacks. Fisher's exact test (2-tailed). §Mann Whitney U test. §Based on 500 myelitis attacks with either (sensori)motor or sensory symptoms; 3 further documented attacks were only associated with other symptoms such as bladder/bowel dysfunction or spasticity and were therefore not included in the analysis. MRC = Medical Research Council; MY = myelitis; N = number of patients (not all data were available from all patients); n.s. = not significant.