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Table 8 Clinical events in the early disease course and long-term outcome.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

Early events in the disease course

EDSS outcome in patients with long term follow-up (≥ 100 months)

(median, range; N)

p-level

Motor symptoms at first myelitis*

Sensory symptoms at first myelitis*

7 (1.5-10; 29)

5.25 (2-9; 16)

p < 0.04§

Motor symptoms at onset

Sensory symptoms at onset

8.25 (5.5-10; 8)

4 (2-6.5; 5)

p < 0.007§

Tetraparesis at first myelitis*

Motor symptoms other than tetraparesis at first myelitis*

8.25 (7-10; 8)

6 (1.5-10; 21)

p < 0.003§

> 1 myelitis attacks during the first year

1 myelitis attack during the first year

8 (2.5-10; 7)

5.5 (2-8.5; 11)

p < 0.035§

  1. *Irrespective of whether at disease onset or not. EDSS = expanded disability status scale; N = number of patients. § Mann Whitney U test.