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Table 9 Myelitis, comparison of spinal cord MRI features according to the patients' AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Seropositive Seronegative p-level
Median lesion length, first MRI 6 (1-21; N = 104) 4.5 (2-12; N = 26) n.s.§
Median lesion length, all MRIs 5 (1-21; N = 264) 4 (1-16; N = 47) p < 0.01§
SC lesions ≥ 3 vertebral segments, 1st MRI 134/142 (94.4%) 38/40 (95%)# n.s.
SC lesions ≥ 3 vertebral segments, all MRIs 240/274 (87.6%) 46/51 (90.2%)# n.s.
SC lesions ≥ 6 vertebral segments, 1st MRI 63/115 (54.8%) 10/28 (35.7%) n.s.
SC lesions ≥ 6 vertebral segments, all MRIs 131/264 (49.6%) 12/47 (25.5%) p < 0.003
Patients with entire SC involvement at least once 15/132 (11.4%) 0/36 (0%) p < 0.043
MRIs with more than one lesion 59/274 (21.5%) 9/51 (17.6%) n.s.
Total lesion load*, first MRI 6.5 (1-21; 104) 5 (2-12; 26) p < 0.022§
Total lesion load*, all MRIs 6 (1-21; 264) 5 (1-16; 47) p < 0.006§
Total lesion load > 6 segments*, first MRI 65/104 (62.5%) 11/26 (42.3%) n.s.
Total lesion load > 6 segments*, all MRIs 153/264 (58%) 17/47 (36.2%) p < 0.007
  1. Values are given as median (range, number) or as proportions. If more than one lesion was present in the same MRI, the longest lesion was counted. *Median cumulative length of all lesions present in the same spinal cord MRI. #Note that all seronegative patients with NMO according to Wingerchuk 2006 or LETM had lesions extending over 3 or more vertebral segments at least once per definitionem. Fisher's exact test (2-tailed). § Mann Whitney U test. MRI = magnetic resonance imaging; N = number of patients (not all data were available from all patients); n.s. = not significant; SC = spinal cord.