Figure 1

MX1 expression levels immediately before and 1 month after the start of therapy with subcutaneous IFN-beta. The measured signal intensities are presented in log scale due to the skewed data distribution. Patients with elevated MX1 transcript levels at baseline (MX1_high, n = 7, black dots) showed only a weak gene induction after 1 month of treatment (P-value = 0.156). In contrast, individuals in the MX1_low group (n = 30, red dots) had a significant increase in expression up to the levels of the MX1_high group (P-value = 1.9 × 10^-9). The figure was drawn using the function “ehplot” of the R package “plotrix”.