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Table 1 Clinical and demographic parameters of the two patient cohorts

From: Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevance

Demographic and clinical characteristics

MX1high(n = 11)

MX1low(n = 50)

P - value

Age at study onset (years)

34.8 ± 8.7

38.3 ± 10.4

0.312

Time from diagnosis to therapy (months)

2.4 ± 2.4

11.6 ± 26.6

0.258

EDSS at baseline

2.0 ± 1.5

1.7 ± 1.1

0.510

Number of relapses during the year prior to study onset

1.2 ± 0.4

0.9 ± 0.6

0.172

Gender (women/men)

8/3

34/16

1.000

Type of IFN-beta administered (1a im/1a sc/1b sc)

4/3/4

20/9/21

0.826

  1. Mean ± standard deviation are given for age, disease duration and expanded disability status scale (EDSS) at study onset as well as for the number of relapses in the year prior to treatment. These parameters were tested for differences between patients with low and high endogenous IFN-like activity (patient groups MX1low and MX1high) applying the t-test. For the sex ratio and the administered IFN-beta products, the absolute patient numbers are given and P-values as calculated by Fisher’s exact test. im, intramuscular; sc, subcutaneous.